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The Introductio of hesperetin

February 03,2024

Product name: Hesperetin
CAS No.: 520-33-2
Chemical formula: C16H14O6
Molar mass: 302.28 g·mol−1
Melting point: 226–228 °C (439–442 °F; 499–501 K)
Solubility in other solvents: Sol. EtOH, alkalis
Content: 98% HPLC
Appearance: Light yellow crystalline powder
Plant source: Citrus aurantium



Hesperetin is one of the Citrus bioflavonoid. It is solid substance, light-brown crystalline powder, poorly soluble in water. Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.


Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic,vasoprotective and anticarcinogenic actions.

Mechanism of Action

Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.


Hesperetin has properties of antioxidant,anti-inflammatory, anti-allergic, hypolipidemic,and anticarcinogenic actions. Hesperidin can also act as a vasodilator, which may be useful in Hypertension.
Hesperetin is also used in functional food or dietary supplement as its properties. More studyings are in process to enlarge its use in more industries.


Commercial Hesperetin can be obtained by hydrolyzation from Hesperidin (extracted from immature citrus fruit).

Lianyuan Kang Biotech Co., Ltd. was established in 2011, located in Loudi High-tech Zone, Hunan Province, covering an area of 50 acres of production housing. Now has tens of thousands of acres of bitter orange planting base, is a committed to the deep processing of citrus fruit, citrus functional components comprehensive development and utilization of high-tech enterprises, the company has 29 invention patents, is a set of planting, research and development, production and sales in one of the high-tech enterprises.

Since its establishment, the company has focused on the development of citrus functional ingredients, and has developed five series of products: Sweet flavor series ( Neohesperidin Dihydrochalcone,  NHDC, naringenin dihydrochalcone, compound sweetener), grapefruit extract and derivative series (apigenin, naringin, naringenin, phloretin, grapefruit flavone), Citrus extract and its derivative series (neohesperidin, hesperidin, hesperetin, polymethoxy flavone PMFS, Synephrine, Selaginella extract (Amentoflavone), citrus pectin series (citrus pectin, citrus fiber) and citrus essential oil series (neroli oil, Petitgrain oil, neroli hydrosol). It has applied for 29 invention patents and is committed to providing nutrition and sweet solutions for the food industry.

Kang Biotech focuses on innovation, constantly creates value for customers, and is willing to develop together with customers.



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