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Research progress on the application of Neohesperidin Dihydrochalcone

September 29,2023

In 1963, American scholar O. O. Herowitz used citrus peels as raw materials to make highly sweet sweetener Dihydrochalcone, and after decades of research, people found a variety of Dihydrochalcone sugar compounds, such as Naringin Dihydrochalcone,Neohesperidin Dihydrochalcone, etc.

According to the National Standard for Food Safety Standard, for the Use of Food Additives (GB 2760), Neohesperidin Dihydrochalcone has been allowed to be used as a food spice; As a sweet substance in the "Catalogue of Feed Additives in China" (2013), Neohesperidin Dihydrochalcone belongs to flavonoid derivatives (vitamin P), and its various characteristics make it have broader application prospects.

Internationally, it is listed as a Generally Recognized as Safe Substance (GRAS) by the American Association of Food Flavors and Extracts Manufacturers (FEMA) and in the Codex for Food Chemicals, Eighth Edition (US-FCC8); The EU is included in the List of Food Flavoring Agents and the European Pharmacopoeia; Approved as a "flavoring substance" by the Australian National Food Administration; It is used as a "flavoring agent" in Japan.


1.1 high sweetness, high-calorie sweetness (is 1500~1800 times the sweetness of sucrose), refreshing taste, long-lasting aftertaste, excellent shielding bitterness effect, Neohesperidin Dihydrochalcone glycoside in the human body hydrolysis, glycosyl group does not participate in metabolism, so its thermal energy value is extremely small (8.36J/g), can be used as a low-energy food sweetener.

1.2 Slow sweetness, long time, slow sweetness, long aftertaste duration (57s), refreshing and pleasant sweetness, and the time for sweetness to reach the maximum is longer than saccharin (42s) and sucrose (24s).

1.3 Good stability, non-toxicity, fast metabolism, whether used in acidic and alkaline environments, its properties are very stable, is the most stable safe sweetener known and increases the broad spectrum of applications.

1.4 It has seasoning characteristics such as sweetening, flavoring, flavoring and masking bitterness.

1.5 It has antioxidant properties, physiological activities such as reducing cholesterol and lowering blood sugar


2.1 Food sweetener/sweetness enhancer is used in combination with sucralose, polyol sweetener, saccharin, etc., which has a strong synergistic effect, that can improve sweetness, reduce the amount of sweetener, reduce costs, and make the sweetness more pure. Widely used in fruit juice drinks, milk, fruit wine, desserts, baked goods, candy, chewing gum, sauces, low-energy drinks, pickles, vinegar, betel nut, cold fruit, etc. An application's addition of Neohesperidin Dihydrochalcone to carbonated beverages can improve the product's sourness, astringency and poor aftertaste. In Belgium, NHDC is added to sugar-free chewing gum and lemon tea, in Spain NHDC is added to soft drinks, and in Switzerland is added NHDC to a variety of sugar-free, low-energy foods and ingredients.

2.2 NHDC, a sweetener of functional food/health products, does not undergo calorie conversion in the body, is a low-calorie value sweetener, and has physiological activities such as hypoglycemia, cholesterol reduction, and antioxidants. It is especially suitable for functional foods, health products, dietary supplements and other health foods as sugar substitutes.

2.3 The physiological function of NHDC, a raw material for drugs and cosmetics, determines the raw materials that can be used to manufacture pharmaceutical raw materials that lower blood lipids and blood sugar, hepatoprotection and gastric drugs.

2.4 Flavor correctors (bitter maskers) and flavor modifiers NHDC can act on bitter taste receptors when they are lower than the sweetness threshold, thereby improving the threshold of bitter taste, and the bitterness removal effect is significantly better than that of general sweeteners. Adding NHDC to walnut soy milk can reduce the aftertaste of "walnuts"; Can mask the vinegar taste and spicy smell in tomato sauce; Compounding with stevia can overcome the bitterness of stevia, and compounding with AK sugar can suppress its metallic taste. The European version of Viagra and pediatric ibuprofen suspension uses NHDC to mask the bitter taste of the drug. NHDC as a flavor enhancer and aspartame mixture can be applied to chewing gum, not only sweet and delicious, but also to prolong and maintain flavor. When added to margarine, it can increase the flavor and smell of butter; Added in fruit products to enhance fruit flavor.

2.5 The flavor type of food flavor and fragrance NHDC is similar to maltol and ethyl maltol and can produce obvious synergistic effects with maltol and ethyl maltol, an application introduced that the addition of NHDC can harmonize, improve and enhance the original flavor in food, thereby improving the flavor, texture and taste of food. Schrader et al. mixed NHDC with oily aromatic compounds, stabilizers, and preservatives to prepare liquid flavors and flavoring compositions, which have a flavor-enhancing effect on the target food.

2.6 The use in feed as a sweetener added to the feed can make the feed taste super sweet, increase the appetite of piglets, significantly promote its growth and reduce feed consumption per kilogram of weight gain, Neohesperidin Dihydrochalcone and other sweeteners when used in combination, especially with saccharin, can produce excellent synergy. Daly et al. found that NHDC has a prebiotic-like effect, adding NHDC to piglet feed, with the increase of lactic acid concentration in the intestinal lumen, the lactobacillus in the cecal entrance of pigs also increases significantly, which can affect the symbiotic intestinal flora, regulate its immunity, and reduce intestinal diseases. Adding this kind of compound sweetener products to animal diets can greatly improve the flavor and palatability of feed, cover up and improve the unfavorable bitter taste of some components in the diet (such as some protein raw materials, vitamins, metal ions and some pharmaceutical ingredients, etc.), thereby enhancing the appetite of young animals and promoting their growth. Zong Minling et al. introduced that the feed additives composed of Neohesperidin Dihydrochalcone and polysaccharides (astragalus polysaccharides, eleuthero polysaccharides, licorice polysaccharides) can replace or reduce antibiotics and drug additives such as growth hormone; Improve sow production performance, shorten the farrowing process of sows, recover quickly after farrowing, and have a large feed intake; The piglets that consumed the premix had a large feed intake and a low feed-to-meat ratio; Chickens eating this premix have a low incidence of Newcastle disease.


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