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Efficacy and effect of hesperetin

January 03,2024

Hesperetin is a natural flavonoids, widely found in fruits, flowers, food and other plant sources.

 It mainly comes from  hesperidin  hydrolysis, has biological and pharmacological activities, and is widely used in organic chemistry, medicine, agriculture, food and other fields.

(1)Antioxidant effect: hesperetin can avoid the harm caused by peroxidation reaction by removing peroxynitrite root ions.

(2)Anti-inflammatory effect: hesperetin can inhibit the mediating effect of inflammatory mediators, thus indirectly inhibiting inflammatory response. Compared with hesperidin, hesperin has a stronger anti-inflammatory effect, which affects its anti-inflammatory activity after connecting hesperetin C7 with rassate.

(3) Hypolipidemic effect: hesperetin can inhibit the effect of cholesterol-producing enzymes and esterification enzymes, so as to achieve the effect of lowering blood lipid.

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Hesperetin has the effect of reducing blood lipid and vascular permeability, and can play a role in preventing thrombosis. Hesperetin can also protect the hypoxia of endothelial cells by stimulating some mitochondrial enzymes, such as succinate dehydrogenase, and prevent the coagulation caused by endothelial cell necrosis and induce thrombosis. In addition, hesperetin promotes antiplatelet coagulation activity by inhibiting the phosphorylation of PLC γ 2 and its downstream signaling, which can prevent the formation of thrombosis and favor the cardiovascular system.

Hesperetin has an antioxidant effect, thus avoiding carcinogenesis caused by genetic changes caused by these factors. Promoting the P-glycoprotein-mediated efflux of drugs from tumor cells, flavonoids (hesperetin, etc.) can alter the permeability of the blood-brain barrier to vincristine, and it is also related to its concentration. Low concentration of flavonoids reduces the uptake of vincristine by brain capillary endothelial cells; high concentration promotes.

Hesperetin is used in health drugs and health products, such as Amway products have added hesperetin. The United States hot-selling health care products vitality 50, its main active ingredient is also hesperetin.

As additives to some cosmetics, such as CLARINS (Clarins) evening creams contain hesperidin. 

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It is also used in food in Japan as an additive with vitamin p action. In China, hesperetin is mainly used as a drug raw material, and the main efficacy of related drugs includes stomach strengthening, expectorant, expectoration, cough, wind repellent, diuresis, restraint and stomachache.

Lianyuan Kang Biotech Co., Ltd. was established in 2011, located in Loudi High-tech Zone, Hunan Province, covering an area of 50 acres of production housing. Now has tens of thousands of acres of bitter orange planting base, is a committed to the deep processing of citrus fruit, citrus functional components comprehensive development and utilization of high-tech enterprises, the company has 29 invention patents, is a set of planting, research and development, production and sales in one of the high-tech enterprises.

Since its establishment, the company has focused on the development of citrus functional ingredients, and has developed five series of products: Sweet flavor series (Neohesperidin Dihydrochalcone, NHDC, naringenin dihydrochalcone, compound sweetener), grapefruit extract and derivative series (apigenin, naringin, naringenin, phloretin, grapefruit flavone), Citrus extract and its derivative series (neohesperidin, hesperidin, hesperetin, polymethoxy flavone PMFS, Synephrine, Selaginella extract (Amentoflavone), citrus pectin series (citrus pectin, citrus fiber) and citrus essential oil series (neroli oil, Petitgrain oil, neroli hydrosol). It has applied for 29 invention patents and is committed to providing nutrition and sweet solutions for the food industry.

Kang Biotech focuses on innovation, constantly creates value for customers, and is willing to develop together with customers.


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