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Academician Shan Yang's team has made a new breakthrough in the research of Neohesperidin Dihydrochalcone

Time : 2023-09-28 Hits : 32

With the improvement in living standards, our diet has changed significantly. High-sugar, high-fat diets are gradually dominating. Long-term high-fat diets will lead to increased levels of total cholesterol (TC) and triglycerides (TG), as well as disorders of glycolipid metabolism. Neohesperidin Dihydrochalcone (NHDC) is a new high-power sweetener derived from citrus that also has strong antioxidant and free radical scavenging activities. Recently, the research team of Academician Shan Yang has made a new breakthrough in the research of Neohesperidin Dihydrochalcone (NHDC) to improve the glycolipid metabolism disorders induced by a high-fat diet, and the relevant results are "Neohesperidin Dihydrochalcone Ameliorates High-FatDiet-Induced Glycolipid Metabolism Disorder in Rats" The title was published in the Journal of Agricultural and Food Chemistry, a top journal in the field of agriculture and forestry science and food science, and the 2019 doctoral student of our institute became the first author of the paper, Academician Shan Yang and Associate Professor Yang Guliang were the corresponding authors, and Longping Branch of the Graduate School of Hunan University was the first unit. The research was supported by the Hunan Kanglu Biomedical Technology Innovation and Entrepreneurship Team and the Central Guidance Local Science and Technology Development Fund (2022ZYC044). 

The study was conducted by giving rats on a high-fat diet experimental gavage to NHDC. The results showed that NHDC significantly reduced FPG and FPI levels, and NHDC upregulated the expression levels of GLUT-4 and IRS-1 proteins. In terms of anti-inflammatory mechanism, the study found that the expression level of key proteins in the TLR4/MyD88/NF-κB pathway was significantly downregulated after NHDC treatment. In terms of energy metabolism pathway, NHDC significantly promoted the phosphorylation level of AMPK in liver tissues and upregulated the expression of SIRT1 and PGC-1α. It was shown that NHDC alleviated the abnormalities of blood lipid metabolism induced by a high-fat diet by promoting the body's energy metabolism. At the same time, NHDC treatment alleviated the degeneration of liver fat induced by a high-fat diet, improved ileal pathological damage, increased SCFA levels, and increased the degree of intestinal tightness.

Through intestinal microbiota sequencing and correlation analysis, it was found that the activity of NHDC in reducing abnormal glucose and lipid metabolism caused by a high-fat diet was related to regulating the composition of intestinal bacteria, downregulating inflammation levels, and promoting the synthesis of SCFA.

This study investigated the effect of NHDC on the abnormalities of blood lipid metabolism induced by a high-fat diet and its possible mechanism. It provides a new idea for the development and utilization of NHDC's sugar substitutes.


Figure 1 NHDC treatment inhibited obesity induced by high-fat diet in rats 


Figure 2 Effects of NHDC on liver pathology and blood lipid levels in rats fed with high fat 

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